- CAS No.
- Chemical Name:
- TRYPTOPHAN;TRP;H-TRP-OH;TRYPTOPHANE;L-TRYPTOPHANE;L-Trp;L-Trp-OH;(s)-2-amino-3-(1h-indol-3-yl)propanoic acid;H-DL-TRP-OH;DL-TRYPTOPHANE
- Molecular Formula:
- Molecular Weight:
- MDL Number:
- MOL File:
- MSDS File:
|Melting point||289-290 °C (dec.)(lit.)|
|alpha||-31.1 º (c=1, H20)|
|Boiling point||342.72°C (rough estimate)|
|refractive index||-32 ° (C=1, H2O)|
|solubility||20% NH3: 0.1 g/mL at 20 °C, clear, colorless|
|color||White to yellow-white|
|PH||5.5-7.0 (10g/l, H2O, 20℃)|
|optical activity||[α]20/D 31.5±1°, c = 1% in H2O|
|Water Solubility||11.4 g/L (25 ºC)|
|Stability||Stable. Incompatible with strong acids, strong oxidizing agents.|
|CAS DataBase Reference||73-22-3(CAS DataBase Reference)|
|FDA 21 CFR||582.5915; 172.320; 310.545|
|Substances Added to Food (formerly EAFUS)||L-TRYPTOPHAN|
|EWG's Food Scores||1|
|NIST Chemistry Reference||L-Tryptophan(73-22-3)|
|EPA Substance Registry System||L-Tryptophan (73-22-3)|
Risk and Safety Statements
|Toxicity||LD508mmol / kg (rat, intraperitoneal injection). It is safe when used in food (FDA, §172.320, 2000).|
L-Tryptophan price More Price(82)
|Manufacturer||Product number||Product description||CAS number||Packaging||Price||Updated||Buy|
|Sigma-Aldrich||8.16017||(S)-(-)-Tryptophan for synthesis||73-22-3||25g||$43.8||2023-01-07||Buy|
|Sigma-Aldrich||8.16017||(S)-(-)-Tryptophan for synthesis||73-22-3||100g||$152||2023-01-07||Buy|
|Sigma-Aldrich||51145||L-Tryptophan certified reference material, TraceCERT||73-22-3||100mg||$118||2022-05-15||Buy|
|Sigma-Aldrich||1700501||L-Tryptophan United States Pharmacopeia (USP) Reference Standard||73-22-3||200mg||$475||2022-05-15||Buy|
L-Tryptophan Chemical Properties,Uses,Production
As an essential amino acid, L-Tryptophan is necessary for normal growth in infants and for nitrogen balance in adults, which cannot be synthesized from more basic substances in humans and other animals, suggesting that it is obtained only by intake of tryptophan or tryptophan-containing proteins for human body, which is particularly plentiful in chocolate, oats, milk, cottage cheese, red meat, eggs, fish, poultry, sesame, almonds, buckwheat, spirulina, and peanuts, etc. It can be used as a nutritional supplement for use as an antidepressant, anxiolytic, and sleep aid. Thus, L-Tryptophan can be used for depression, anxiety, sleep apnea, premenstrual syndrome and many other problems. Besides, it can also be used in managing pain tolerance and managing weight.
It works by increasing the levels of certain neurotransmitters in the brain called serotonin. People suffer from depression have an imbalance of serotonin and other brain chemicals. Thus, the increase of serotonin levels in the brain can improve symptoms of depression. L-Tryptopan serves as the precursor for the synthesis of serotonin, which is converted to serotonin in the body. As a result, the symptoms of depression and other problems are improved.
It is also known as α-aminoindolylpropionic acid. Appearance: white to slightly yellowish white crystal or crystalline powder. No smell; Slight bitter taste. Melting temperature: 289 ° C (decomposition); soluble in water. Applications: as food fortifier, antioxidant; also used in medicine. It is manufactured from indole aldehyde, alternatively also be synthesized from trypsin decomposition and synthesis.
Accurately weigh about 300 mg sample and dissolve it in 3ml formic acid and 50ml glacial acetic acid; add 2 drops crystal violet test solution (TS-250), titrate with 0.1mol / L perchloric acid to the green end point or until the blue color completely disappears. Each Ml of 0.1 mol / L perchloric acid corresponds to 20.42 mg of L-tryptophan (C11H12N2O2).
Amino acids-type drug:
It can be used in amino acid infusion, being often combined with iron and vitamins. Its co-administration with VB6 can improve depression and prevention/treatment of skin disease; as a sleep sedative, it can be combined with L-dopa for the treatment of Parkinson's disease. It is carcinogenic to experimental animals; it may cause adverse reactions including nausea, anorexia and asthmas. Avoid combination with monoamine oxidase inhibitors.
Tryptophan contained in egg white protein, fish meat, corn meal and other amino acids are limited; content in cereals such as rice is also low. It can be combined with lysine, methionine and threonine for enhanced amino acids. It can be supplemented to corn product at the content of 0.02% tryptophan and 0.1% lysine, being capable of significantly improving the protein potency.
Appearance: white crystalline powder. Odorless, slightly bitter taste;
Solubility: slightly soluble in water (1.14%, 25 ℃), insoluble in ethanol; soluble in dilute acid or dilute alkali. mp 289 ° C (decomposition).
Isoelectric point: 5.89. [α] D + 2.8 (5 mol / L HCl), [α] D + 6.2 (0.5 mol / L NaOH).
It can be colored upon long-term exposure to light. Its co-heating reaction with water will generate a small amount of indole while heating in the presence of sodium hydroxide and copper sulfate will produce a large amount of indole. It is stable upon heating together with acid in the dark, but is easily to be decomposed when heated together with other amino acids, carbohydrates and aldehydes. L-tryptophan will be completely decomposed when applying acid to break down the protein.
White to off-white crystalline powder
tryptophan is one of the 21 amino acids comprising a protein. Tryptophan is a component of the skin’s natural moisturizing factors.
L-tryptophan is an essential amino acid which is necessary for normal growth in infants and for nitrogen balance in adults. It acts as a natural dietary supplement and used as an antidepressant, anxiolytic and sleep aid. It is used as a precursor to niacin, indole alkaloids and serotonin. It acts as an important intrinsic fluorescent probe, which finds to estimate the nature of microenvironment of the tryptophan.
ChEBI: The L-enantiomer of tryptophan.
World Health Organization (WHO)
L-tryptophan, an essential aminoacid and precursor of serotonin, was introduced into medicine in 1963 for the treatment of depression and sleep disorders. Its effectiveness in these conditions has, however, never been convincingly demonstrated. It is also widely used in dietary supplements, parenteral nutrition preparations and dietary products for children with phenylketonuria. In 1989, reports from the USA showed an association between the consumption of L-tryptophan containing preparations and the development of eosiniphilia-myalgia syndrome (EMS), a condition characterized by intense eosinophilia, severe muscle and joint pain, swelling of the arms and legs, skin rashes and possible fever. Some of the reported cases have been fatal. Since it is not yet clear whether L-tryptophan itself or an unidentified contaminant is the cause of the EMS, many drug regulatory authorities have suspended the marketing authorization of products containing tryptophan pending further investigation, whereas others have withdrawn these products or restricted their use.
The Journal of Organic Chemistry, 49, p. 3711, 1984 DOI: 10.1021/jo00194a008
White powder with a flat taste. An essential amino acid; occurs in isomeric forms.
Air & Water Reactions
Slightly soluble in water.
Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
ACUTE/CHRONIC HAZARDS: When heated to decomposition L-Tryptophan emits toxic fumes.
Flash point data for L-Tryptophan are not available. L-Tryptophan is probably combustible.
Tryptophan (Trp) is one of the functional amino acids that are associated with growth, reproduction, maintenance and immunity. Increased Trp availability is necessary for the regulation of mood, cognition and behaviour. It is hypothesised that L-Trp might be useful in inducing sleep in healthy adults against the normal circadian rhythm. Trp uptake by the brain depends on the plasma ratio of Trp to all of the other LNAAs (large neutral amino acids). Higher the Trp:LNAAs ratio, greater is the Trp uptake.
Moderately toxic by intraperitoneal route. Experimental teratogenic and reproductive effects. Human mutation data reported. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of NOx.
Crystallise L-tryptophan from H2O/EtOH, wash it with anhydrous diethyl ether and dry it at room temperature in a vacuum over P2O5. It sublimes at 220-230o/0.03mm with 99% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Cox & King Org Synth Coll Vol II 612 1943, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2316-2345 1961, Beilstein 22 IV 6765.]
L-Tryptophan Preparation Products And Raw materials
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- L-Tryptophan:Mechanism of action,Safety concerns
- L-tryptophan is an amino acid. Amino acids are protein building blocks. L-tryptophan is called an "essential" amino acid becau....
- Oct 23，2019
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